Original price was: $100.00.$85.00Current price is: $85.00.
Stabilized GHRH analog supplied for visceral adipose, lipid metabolism, and IGF-1 axis research models.
CAS Number: 218949-48-5
Form: Lyophilized Powder
Quantity: 10mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight: 5,136 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Research Compounds
Use: Not for human or animal use. Research laboratory use only.
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Tesa is a synthetic, stabilized analog of growth-hormone-releasing hormone, GHRH(1-44), modified with a trans-3-hexenoic acid group that increases resistance to enzymatic degradation. It acts as an agonist at the growth-hormone-releasing hormone receptor (GHRHR) on pituitary somatotrophs and is classified within the GHRH-analog family. In the research setting described here, Tesa is supplied strictly as a reference material for in vitro and preclinical laboratory investigation of GHRH-receptor pharmacology and somatotropic-axis signaling by qualified professionals. Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption. Tesa is a stabilized analog of GHRH(1-44) in which an N-terminal trans-3-hexenoic acid modification reduces susceptibility to enzymatic cleavage, extending the peptide’s stability relative to native growth-hormone-releasing hormone. Mechanistically, it is a growth-hormone-releasing hormone receptor (GHRHR) agonist acting on pituitary somatotrophs within the somatotropic axis. Tesa has been investigated in randomized published research examining GHRH-receptor agonism; Falutz and colleagues reported on this growth-hormone-releasing factor in placebo-controlled trials.1 Extended-duration and safety-focused investigations of the same GHRH analog have also been documented.2,3 Later randomized published research has further examined GHRH-analog pharmacology in the study populations documented in the literature.4 Across these references, Tesa serves as a well-characterized GHRH-analog probe for research on GHRHR binding, cAMP signaling, and the endocrine circuitry of the growth-hormone axis. It engages the GHRH receptor like native GHRH, which makes it a frequent comparator in receptor-pharmacology studies. The descriptions here concern receptor mechanism and the published research record only; the material distributed is a laboratory reagent, and no human or veterinary use is described or intended. Not for human or animal use. Research laboratory use only.
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