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SS-31, also designated elamipretide, is a synthetic aromatic-cationic tetrapeptide of the Szeto-Schiller series. It concentrates in the inner mitochondrial membrane, where it associates with the phospholipid cardiolipin, and it is used as a reference compound in laboratory studies of mitochondrial membrane structure, electron transport chain efficiency, and reactive oxygen species generation. Precision Research Peptides supplies SS-31 strictly as a reference material for in vitro and preclinical laboratory investigation of mitochondrial bioenergetics and cardiolipin-peptide interactions by qualified professionals. Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption. SS-31 is an aromatic-cationic tetrapeptide (D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂) originally characterized by Zhao and colleagues, who described its cell-permeable, mitochondria-targeted antioxidant properties in isolated mitochondria and cell-based models.1 Subsequent published work has examined its selective binding to cardiolipin in the inner mitochondrial membrane and the resulting effects on cristae architecture and electron transport chain function in preclinical models.2 Reviews of the Szeto-Schiller peptide series describe SS-31 as a well-characterized probe for studying mitochondrial dysfunction, oxidative stress, and bioenergetic failure in laboratory research settings.3 Across these references, SS-31 serves as a standard research tool for investigating cardiolipin-peptide interactions, mitochondrial membrane potential, and reactive oxygen species dynamics. The descriptions here concern mechanism and the published research record only; the material distributed is a laboratory reagent, and no human or veterinary use is described or intended. Not for human or animal use. Research laboratory use only.
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