Original price was: $74.00.$69.00Current price is: $69.00.
Mitochondria-derived research peptide for in vitro applications.
CAS Number: 1627580-64-6
Form: Lyophilized Powder
Quantity: 10mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight: 2,174.6 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Mitochondrial & Metabolic Research
Use: Not for human or animal use. Research laboratory use only.
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MOTS-c (mitochondrial open reading frame of the twelve-S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome. First characterized in 2015, it belongs to a class of small peptides expressed from mitochondrial DNA and studied for their signaling roles between the mitochondria and the nucleus. Supplied as a lyophilized powder for in vitro and preclinical laboratory investigation, this material is intended for qualified researchers examining mitochondrial-derived peptide biology, AMPK-associated signaling, and cellular metabolism research. Each unit is characterized for research identity and purity and provided solely as a reference chemical for controlled laboratory settings.
Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.
MOTS-c was identified through analysis of short open reading frames within mitochondrial 12S ribosomal RNA, establishing it as one of the mitochondrial-derived peptides.1 In published preclinical models, research has examined its role in AMP-activated protein kinase (AMPK) signaling and the folate–methionine one-carbon cycle, positioning the peptide within mitochondrial signaling research and cellular metabolism research.1,2 Subsequent work reported that MOTS-c can translocate to the nucleus under conditions of metabolic stress, where it has been investigated for its role in the regulation of nuclear gene expression and stress-adaptive transcriptional pathways.3 Additional studies have characterized MOTS-c as an exercise-associated, mitochondrial-encoded factor examined in the context of skeletal-muscle homeostasis research and age-associated physiological change in rodent model systems.4 Collectively, this literature frames MOTS-c as a tool compound for investigating mitochondria-to-nucleus retrograde signaling and metabolic-homeostasis research pathways. All statements here summarize published laboratory findings and are provided for scientific reference only; no data are presented as evidence of safety or effect in humans or animals.
Not for human or animal use. Research laboratory use only.
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