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Synthetic tetrapeptide supplied for cellular aging, telomere biology, and circadian pathway research models.
CAS Number: 307297-39-8
Form: Lyophilized Powder
Quantity: 40mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.35 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Research Compounds
Use: Not for human or animal use. Research laboratory use only.
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Epithalon (also written epitalon or epithalone) is a synthetic tetrapeptide with the amino acid sequence alanine–glutamic acid–aspartic acid–glycine (Ala-Glu-Asp-Gly; AEDG). It was developed as a short-peptide counterpart to polypeptide fractions isolated from the pineal gland, and its compact four-residue structure makes it a defined, reproducible reagent for laboratory work. In research settings, Epithalon is studied primarily in the context of telomere and telomerase biology and pineal/circadian regulation. Material supplied under this listing is characterized for identity and purity and is intended solely as a research reagent for controlled in vitro and preclinical laboratory investigation.
Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.
Epithalon (AEDG) is investigated in laboratory research as a synthetic analog of pineal-gland peptide fractions. Analytical work has identified the AEDG peptide within the polypeptide complex of the pineal gland, which underpins its use as a defined structural counterpart in bioregulation research.4 Much of the primary literature originates from Russian-language research groups; a 2025 English-language review in the International Journal of Molecular Sciences consolidates the reported in vitro, in vivo, and in silico findings and frames AEDG as a subject of telomere-biology and neuroendocrine investigation.1 In cell-based studies, Epithalon has been investigated for its role in telomerase activity and telomere-length dynamics in human somatic cell cultures.2 Related work has examined its role in the proliferative behavior of human somatic cells maintained in culture beyond typical division limits.3 Across this body of work, the peptide is examined in the context of telomere/telomerase research and pineal signaling rather than any defined physiological endpoint. Because a substantial portion of the source literature is Russian-language and not uniformly indexed in English databases, findings should be treated as exploratory, and cross-referencing against English-indexed reviews is recommended before drawing mechanistic conclusions.1 Collectively, the verifiable English-indexed literature positions Epithalon as a research reagent for telomere/telomerase biology and pineal-peptide bioregulation studies conducted strictly under laboratory conditions.
Not for human or animal use. Research laboratory use only.
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