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Long-R3 IGF-1 synthetic analog supplied for growth-factor signaling and IGF-1 receptor research models.
CAS Number: [PENDING — Frank to supply from supplier COA]
Form: Lyophilized Powder
Quantity: 1mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: [PENDING — Frank to supply from supplier COA]
Molecular Weight: [PENDING — Frank to supply from supplier COA]
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Research Compounds
Use: Not for human or animal use. Research laboratory use only.
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IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is an 83-amino-acid recombinant analog of human insulin-like growth factor 1 (IGF-1). Its structure combines a 13-amino-acid N-terminal extension with an arginine-for-glutamate substitution at position 3 of the native IGF-1 sequence. Together these modifications lower the molecule’s binding affinity for insulin-like growth factor binding proteins (IGFBPs) relative to native IGF-1 — a property that has established it as a reference reagent in laboratory studies of IGF-1 receptor signaling and cell-culture systems. Material supplied under this listing is characterized for identity and purity and is distributed strictly as a research reagent for controlled in vitro and preclinical laboratory investigation.
Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.
IGF-1 LR3 is used in laboratory research as a structurally modified analog of insulin-like growth factor 1. Nuclear magnetic resonance characterization has described the solution structure and backbone dynamics of long-[Arg3]IGF-I, establishing how the N-terminal extension and the position-3 substitution alter the molecule relative to native IGF-1.1 Because these modifications lower affinity for insulin-like growth factor binding proteins (IGFBPs), the analog has been investigated for its role in IGF-1 receptor (IGF-1R) signaling systems in which binding-protein interference is an experimental variable.1 In whole-organism models, long R3 IGF-I infusion has been examined for its role in organ growth pathways and in the regulation of circulating IGF-I, IGF-II, and IGF binding protein concentrations.2 Comparative in vitro work has investigated how IGF-I and long R3 IGF-I differentially affect transcript abundance for IGF-binding proteins and type I IGF receptors during early embryonic development, informing research on receptor-mediated signaling.3 In cell-culture applications, LONG R3 IGF-I has been studied as a defined supplement in serum-free HEK293 systems, where its reduced binding-protein affinity has been characterized relative to insulin.4 Taken together, this literature frames IGF-1 LR3 as an experimental reference reagent for probing IGF-1 receptor signaling, binding-protein biology, and comparative growth-factor behavior under controlled conditions.
Not for human or animal use. Research laboratory use only.
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I understand these products are for research use only and not for use in people or pets. I am purchasing these items for laboratory or research purposes only. They are not for human or animal use, not medicine, and not for diagnosing, treating, or curing any condition. I will follow all applicable laws and safe handling rules. I accept that this website, and our affiliates, are not responsible for how I use or store these items once delivered, to the fullest extent allowed by law. In accordance with industry guidelines, access to this website is restricted to individuals 21 years of age or older. This site provides information and products strictly for laboratory and research use. Are you over 21 years of age?
