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Selective pentapeptide growth-hormone secretagogue supplied for endocrine signaling and ghrelin-receptor research models.
CAS Number: 170851-70-4
Form: Lyophilized Powder
Quantity: 10mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: 711.9 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Research Compounds
Use: Not for human or animal use. Research laboratory use only.
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Ipamorelin is a synthetic pentapeptide classified as a selective growth-hormone secretagogue (GHS) and a member of the growth-hormone-releasing peptide (GHRP) family. It functions as an agonist at the growth hormone secretagogue receptor (GHS-R1a), the same receptor recognized by the endogenous peptide ghrelin. In laboratory settings, ipamorelin serves as a reference compound for studies of somatotroph signaling and GHS-R1a receptor pharmacology, and it is noted in the peer-reviewed literature for its receptor selectivity relative to earlier secretagogues. This material is distributed strictly as a research chemical for in vitro and preclinical laboratory investigation by qualified professionals working in appropriately controlled environments. Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) is a pentapeptide first characterized by Raun and colleagues, who described it as the first selective growth-hormone secretagogue and mapped its activity to the growth hormone secretagogue receptor.1 This receptor, later designated GHS-R1a, is the same G-protein-coupled receptor for which ghrelin was subsequently identified as the endogenous acylated-peptide ligand.2 Research into the GHS-R has localized its expression to the pituitary and hypothalamus, where it participates in the regulation of growth-hormone release from somatotrophs.3 Ipamorelin has been investigated for its role in this GHS-R1a-mediated pathway, and comparative pharmacology work has examined its selectivity profile alongside other peptidomimetic secretagogues.4 Within the framework of somatotropic-axis research, ipamorelin is studied as a tool compound for probing receptor-binding behavior, intracellular signaling, and the endocrine circuitry of the growth-hormone axis. It acts at the GHS-R1a like other GHRP-class peptides, which makes it a common reference point in receptor-comparison and structure-activity studies. All applications described here concern in vitro systems, receptor assays, and controlled preclinical models; no human or veterinary application is described or intended.
Not for human or animal use. Research laboratory use only.
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