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Synthetic GHRH analog (1-29) supplied for endocrine axis and pituitary signaling research models.
CAS Number: 86168-78-7
Form: Lyophilized Powder
Quantity: 5mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: 3,357.9 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Research Compounds
Use: Not for human or animal use. Research laboratory use only.
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Sermorelin acetate is the acetate salt of sermorelin, a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of endogenous growth-hormone-releasing hormone, GHRH(1-29). It is characterized in the literature as a GHRH analog that acts as an agonist at the growth-hormone-releasing hormone receptor (GHRHR) expressed on pituitary somatotrophs. In research settings, sermorelin is used as a reference compound for studies of GHRH-receptor pharmacology and somatotropic-axis signaling. This material is supplied strictly as a research chemical for in vitro and preclinical laboratory investigation by qualified professionals working in appropriately controlled environments. Not for human or animal use. Research laboratory use only.
All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.
Sermorelin corresponds to GHRH(1-29)NH2, the shortest N-terminal sequence of human growth-hormone-releasing hormone that retains full activity at the GHRH receptor. Walker discussed sermorelin in the context of the somatotropic axis and GHRH-based approaches within growth-hormone-axis research.1 Prakash and Goa reviewed sermorelin as a GHRH(1-29) analog, characterizing its receptor identity and pharmacology.2 The molecular target, the GHRH receptor, is a pituitary-specific G-protein-coupled receptor cloned and characterized by Mayo, whose work established the receptor basis for GHRH and GHRH(1-29) signaling in somatotrophs.3 Earlier physiological studies of growth-hormone-releasing factor in humans helped define the responsiveness of the somatotropic axis to GHRH-class peptides and remain reference points for GHRH-receptor research.4 Within this framework, sermorelin is studied as a tool compound for investigating GHRH-receptor binding, downstream cAMP signaling, and the endocrine regulation of the growth-hormone axis. It acts at the GHRHR like the full-length endogenous hormone, which makes it a common reference peptide in receptor-comparison and structure-activity studies. All applications described concern in vitro assays and controlled preclinical models; no human or veterinary use is described or intended.
Not for human or animal use. Research laboratory use only.
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