TB-500 (Thymosin B4 Acetate)

Original price was: $49.00.Current price is: $41.65.

Thymosin Beta-4 (TB-500) supplied for cell migration, tissue remodeling, and regenerative biology research models.
Batch Certification
≥99%HPLC Purity
Third-party tested · Batch-matched COA
Specifications
CAS Number: 885340-08-9
Form: Lyophilized Powder
Quantity: 5mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₃₈H₆₈N₁₀O₁₄
Molecular Weight: 889.0 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Research Category: Recovery & Tissue Research
Use: Not for human or animal use. Research laboratory use only.
Batch Certification
≥99% HPLC Purity
Third-party tested · Batch-matched COA

View certificate of analysis — lot [LOT_PENDING — Frank to supply] →

Thymosin Beta-4 (TB-500) supplied for cell migration, tissue remodeling, and regenerative biology research models.

CAS Number: 885340-08-9
Form: Lyophilized Powder
Quantity: 5mg per vial
Purity: ≥99% (HPLC verified)
Molecular Formula: C₃₈H₆₈N₁₀O₁₄
Molecular Weight: 889.0 g/mol
Storage: −20°C recommended
Stability: 24+ months lyophilized
Category: Recovery & Tissue Research
Use: Not for human or animal use. Research laboratory use only.

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Product Overview

TB-500 is a synthetic peptide corresponding to the biologically active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid, actin-sequestering protein present in most mammalian cell types. Supplied as the acetate salt, TB-500 is used in laboratory settings as a reference form of the Tβ4 actin-binding motif, centered on the conserved LKKTETQ sequence. In the preclinical literature, Thymosin Beta-4 has been investigated for its role in actin regulation, cell migration, angiogenic signaling, and matrix and tissue remodeling across in vitro and animal model systems. Precision Research Peptides offers TB-500 (Thymosin Beta-4 Acetate) strictly as a research reference material for controlled experimentation.

Not for human or animal use. Research laboratory use only.

All compounds referenced are supplied for laboratory and research applications only and are not for human consumption.

TB-500 is the research designation for a synthetic form of Thymosin Beta-4 (Tβ4), an endogenous actin-sequestering peptide. Its most characterized biochemical property is the binding and sequestration of monomeric G-actin; reviews describe Tβ4 as the major actin-sequestering molecule in mammalian cells, a role that has been investigated in the context of cytoskeletal dynamics and cell motility.1 This actin-binding activity is not purely structural: research has localized an angiogenesis-associated site to the actin-binding region of the molecule, reporting that this domain is associated with vascular formation in experimental systems.2

In endothelial cell assays, Tβ4 has been examined for its role in directional cell migration, a process central to angiogenesis and matrix-remodeling research.3 Animal-model reviews have further catalogued Tβ4 investigation across dermal, corneal, and cardiac tissue-repair systems, framing it as a multifunctional regeneration-research peptide rather than a defined research reagent.4 Across this literature, Tβ4 shares actin-regulatory and pro-migratory pathways of interest with other cytoskeletal-active agents studied in tissue-remodeling research. Reported findings derive from in vitro and animal models and have not been established in humans.

Not for human or animal use. Research laboratory use only.

References

  1. Goldstein AL, Hannappel E, Kleinman HK. 2005;11(9):421-429. PMID: 16099219. https://pubmed.ncbi.nlm.nih.gov/16099219/
  2. Philp D, Huff T, Gho YS, et al. 2003;17(14):2103-2105. PMID: 14500546. https://pubmed.ncbi.nlm.nih.gov/14500546/
  3. Malinda KM, Goldstein AL, Kleinman HK. 1997;11(6):474-481. PMID: 9194528. https://pubmed.ncbi.nlm.nih.gov/9194528/
  4. Philp D, Kleinman HK. 2010;1194:81-86. PMID: 20536453. https://pubmed.ncbi.nlm.nih.gov/20536453/
For laboratory research use only. Not for human or veterinary consumption.

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I understand these products are for research use only and not for use in people or pets. I am purchasing these items for laboratory or research purposes only. They are not for human or animal use, not medicine, and not for diagnosing, treating, or curing any condition. I will follow all applicable laws and safe handling rules. I accept that this website, and our affiliates, are not responsible for how I use or store these items once delivered, to the fullest extent allowed by law. In accordance with industry guidelines, access to this website is restricted to individuals 21 years of age or older. This site provides information and products strictly for laboratory and research use. Are you over 21 years of age?

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